| Character | Description/role | First appearance |
|---|
| Simpson, HomerHomer Simpson | Husband of Marge; father of Bart, Lisa, and Maggie. | "Good Night" (The Simpsons shorts)[3] |
| Simpson, MargeMarge Simpson | Wife of Homer; mother of Bart, Lisa, and Maggie. | "Good Night"[3] |
| Simpson, BartBart Simpson | Oldest child and only son of Homer and Marge; brother of Lisa and Maggie. | "Good Night"[3] |
| Simpson, LisaLisa Simpson | Middle child and oldest daughter of Homer and Marge; sister of Bart and Maggie. | "Good Night"[3] |
| Simpson, MaggieMaggie Simpson | Youngest child and daughter of Homer and Marge; sister of Bart and Lisa. | "Good Night"[3] |
| Akira | Waiter at The Happy Sumo;[6] karate teacher.[7] | "One Fish, Two Fish, Blowfish, Blue Fish" |
| Albright, Ms. Ms. Albright | Sunday school teacher. | "The Telltale Head" |
| Amadopolis, Aristotle Aristotle Amadopolis | Owner of the Shelbyville Nuclear Power Plant.[10] | "Homer Defined" |
| Atkins Atkins, State Comptroller | State comptroller.[13] | "Lisa Gets an 'A'" |
| Bailey, Mary Mary Bailey | Governor of Springfield's state. | "Two Cars in Every Garage and Three Eyes on Every Fish" |
| Barlow Birchibald "Birch" T. Barlow | Radio talk show host; Fox News anchor. | "Sideshow Bob Roberts" |
| Beardly, Jasper Jasper Beardly | Springfield Retirement Castle resident. | "Homer's Odyssey" |
| Benjamin, Doug, and Gary | Springfield University students. | "Homer Goes to College" |
| Bill and Marty | KBBL Radio co-hosts. | "Bart vs. Thanksgiving" |
| Blinky | Three-eyed fish. | "Two Cars in Every Garage and Three Eyes on Every Fish" |
| Boobarella | Host of late night TV monster movies. | "I'm Spelling as Fast as I Can" |
| Borton Wendell Borton | Student at Springfield Elementary School. | "Homer's Odyssey" |
| Bouvier, Jacqueline Jacqueline Bouvier | Mother of Selma and Patty Bouvier and Marge Simpson. | "Bart vs. Thanksgiving" |
| Bouvier, PattyPatty Bouvier | Twin sister of Selma and older sister of Marge. | "Simpsons Roasting on an Open Fire" |
| Bouvier, SelmaSelma Bouvier | Twin sister of Patty and older sister of Marge. | "Simpsons Roasting on an Open Fire" |
| Brockman, KentKent Brockman | News anchor. | "Krusty Gets Busted" |
| Bumblebee Man | Star of slapstick sketch comedy show on Canal Ocho. | "Itchy & Scratchy: The Movie" |
| Burns, Charles MontgomeryCharles Montgomery Burns | Owner of the Springfield Nuclear Power Plant. | "Simpsons Roasting on an Open Fire" |
| Blue-Haired Lawyer[14] | Attorney. | "Bart Gets Hit by a Car" |
| Capital City Goofball | Mascot of the Capital City Capitals baseball team.[16] | "Dancing Homer" |
| Carlson, CarlCarl Carlson | Springfield Nuclear Power Plant employee. | "Homer's Night Out" |
| Crazy Cat Lady[11] | Mentally ill owner of many cats. Name revealed as Eleanor Abernathy in "See Homer Run". | "Girly Edition" |
| Chalmers, Superintendent GarySuperintendent Gary Chalmers | Public schools superintendent. | "Whacking Day" |
| Charlie | Springfield Nuclear Power Plant employee. | "Life on the Fast Lane" |
| Chase | Luann Van Houten's ex-boyfriend; American Gladiator. | "A Milhouse Divided" |
| Christian, ScottScott Christian | News co-anchor. | "Krusty Gets Busted" |
| Cowboy Bob | RV salesman.[19] | "The Call of the Simpsons" |
| Comic Book Guy | Proprietor of The Android's Dungeon comic book store. Name revealed to be Jeff Albertson in "Homer and Ned's Hail Mary Pass". | "Three Men and a Comic Book" |
| Costington, Mr.Mr. Costington | President of Costington's Department Store. | "Trash of the Titans" |
| Database | Student at Springfield Elementary School. | "Bart's Comet" |
| Desmond, DeclanDeclan Desmond | Documentary filmmaker. | "'Scuse Me While I Miss the Sky" |
| Disco Stu | Disco aficionado. | "Two Bad Neighbors" |
| Dolph | Springfield Elementary School bully. | "The Telltale Head" |
| Doris, LunchladyLunchlady Doris | Springfield Elementary School lunch lady. | "Lisa's Pony" |
| Duffman | Spokes-mascot for Duff Beer. | "The City of New York vs. Homer Simpson" |
| Eddie and Lou | Springfield police officers. | "There's No Disgrace Like Home" |
| Ernst and Gunter | Lion tamers. | "$pringfield (or, How I Learned to Stop Worrying and Love Legalized Gambling)" |
| Fat Tony | Mob boss. | "Bart the Murderer" |
| Flanders, MaudeMaude Flanders | Ned Flanders's deceased wife. | "Dead Putting Society" |
| Flanders, NedNed Flanders | The Simpson family's next door neighbor; owner of The Leftorium. | "Simpsons Roasting on an Open Fire" |
| Flanders, RodRod Flanders | Ned and Maude Flanders's elder son. | "Dead Putting Society" |
| Flanders, ToddTodd Flanders | Ned and Maude Flanders's younger son. | "Simpsons Roasting on an Open Fire" |
| Frankie the Squealer | Informant for Fat Tony.[20] | "Insane Clown Poppy" |
| Frink, Professor JohnProfessor John Frink | Scientist, inventor. | "Old Money" |
| Gerald, BabyBaby Gerald | One-eyebrowed baby. | "Sweet Seymour Skinner's Baadasssss Song" |
| Ginger | Ned Flanders's "Vegas wife."[21] | "Viva Ned Flanders" |
| Glick, Mrs.Mrs. Glick | Elderly. | "Three Men and a Comic Book" |
| Gloria | Snake's pregnant girlfriend. | "A Hunka Hunka Burns in Love" |
| Gumble, BarneyBarney Gumble | Barfly. | "Simpsons Roasting on an Open Fire" |
| Gunderson, GilGil Gunderson | Unsuccessful Salesman. | "Realty Bites" |
| Happy Little Elves | Children's cartoon series characters. | "Scary Movie" (The Simpsons shorts)[24] |
| Harm, Judge ConstanceJudge Constance Harm | Springfield judge. | "The Parent Rap" |
| Herman | Owner of Herman's Military Antiques shop.[25] | "Bart the General" |
| Hibbert, BerniceBernice Hibbert | Dr. Hibbert's wife. | "Bart's Dog Gets an F" |
| Hibbert, Dr. JuliusDr. Julius Hibbert | Medical doctor. | "Bart the Daredevil" |
| Hoover, Miss ElizabethMiss Elizabeth Hoover | Lisa Simpson's teacher at Springfield Elementary School. | "Lisa's Substitute" |
| Hutz, LionelLionel Hutz | Attorney. | "Bart Gets Hit by a Car" |
| Itchy & Scratchy | Cartoon cat and mouse. | "The Bart Simpson Show" (The Simpsons shorts)[27] |
| Jacques | Bowling instructor.[29] | "Life on the Fast Lane" |
| Jones, JimboJimbo Jones | Springfield Elementary School bully. | "The Telltale Head" |
| Jordan, RachelRachel Jordan | Lead singer of the Christian Rock band Kovenant.[31] | "Alone Again, Natura-diddily" |
| Kang and Kodos | Extraterrestrials. | "Treehouse of Horror" |
| Kashmir, PrincessPrincess Kashmir | Belly dancer.[32] | "Homer's Night Out" |
| Kearney | Springfield Elementary School bully. | "The Telltale Head" |
| Krabappel, EdnaEdna Krabappel | Bart Simpson's teacher at Springfield Elementary School. | "Bart the Genius" |
| Krustofski, Rabbi HymanRabbi Hyman Krustofski | Rabbi; father of Krusty the Clown.[34] | "Like Father, Like Clown" |
| Krusty the Clown | TV show clown host. | "The Krusty the Clown Show" (The Simpsons shorts)[35] |
| Kwan, CookieCookie Kwan | Real estate agent.[36] | "Realty Bites" |
| Largo, DeweyDewey Largo | Springfield Elementary School's music teacher. | "Simpsons Roasting on an Open Fire" |
| Legs and Louie | Fat Tony's henchmen. | "Bart the Murderer" |
| Leopold | Superintendent Chalmers' assistant. | "Sweet Seymour Skinner's Baadasssss Song" |
| Leonard, LennyLenny Leonard | Springfield Nuclear Power Plant employee; one of Homer Simpson's friends. | "Life on the Fast Lane" |
| Lewis | Student at Springfield Elementary School. | "Simpsons Roasting on an Open Fire" |
| Lovejoy, HelenHelen Lovejoy | Reverend Lovejoy's wife. | "Life on the Fast Lane" |
| Lovejoy, Reverend TimothyReverend Timothy Lovejoy | Minister of the First Church of Springfield. | "The Telltale Head" |
| Lugash | Gymnastics instructor.[37] | "Children of a Lesser Clod" |
| Luigi | Italian restaurant proprietor. | "Sweet Seymour Skinner's Baadasssss Song" |
| Lumpkin, LurleenLurleen Lumpkin | Country music singer/songwriter. | "Colonel Homer" |
| Malibu Stacy | Doll. |
|
| Mann, OttoOtto Mann | Springfield Elementary School bus driver. | "Homer's Odyssey" |
| McCallister, Captain HoratioCaptain Horatio McCallister | Sea captain. | "New Kid on the Block" |
| Meyers, Jr., RogerRoger Meyers, Jr. | President of Itchy & Scratchy Studios. | "Itchy & Scratchy & Marge" |
| McClure, TroyTroy McClure | Actor. | "Homer vs. Lisa and the 8th Commandment" |
| Moleman, HansHans Moleman | Misfortunate man. | "Principal Charming" |
| Monroe, Dr. MarvinDr. Marvin Monroe | Psychotherapist. | "There's No Disgrace Like Home" |
| Muntz, NelsonNelson Muntz | Springfield Elementary School bully. | "Bart the General" |
| Muntz, Mrs.Mrs. Muntz | Nelson Muntz's mother. |
|
| Murdock, Captain LanceCaptain Lance Murdock | Daredevil. | "Bart the Daredevil" |
| Murphy, Bleeding GumsBleeding Gums Murphy | Blues musician.[42] | "Moaning Lisa" |
| Nahasapeemapetilon, ApuApu Nahasapeemapetilon | Operator of the Kwik-E-Mart. | "The Telltale Head" |
| Nahasapeemapetilon, ManjulaManjula Nahasapeemapetilon | Apu Nahasapeemapetilon's wife. | "Much Apu About Nothing" |
| Nahasapeemapetilon, SanjaySanjay Nahasapeemapetilon | Apu Nahasapeemapetilon's older brother. | "Homer vs. Lisa and the 8th Commandment" |
| Naegle, LindseyLindsey Naegle | Corporate executive. | "The Itchy & Scratchy & Poochie Show" |
| Old Barber | Barber. | "Bart's Haircut" (The Simpsons shorts)[45] |
| Old Jewish Man | Springfield Retirement Castle resident. | "Krusty Gets Kancelled" |
| Patches and Poor Violet | Orphans.[46] | "Miracle on Evergreen Terrace" |
| Pye, ArnieArnie Pye | Helicopter reporter. | "Homer Alone" |
| Poochie | Cartoon dog formerly on The Itchy & Scratchy Show. | "The Itchy & Scratchy & Poochie Show" |
| Powell, HerbertHerbert Powell | Homer Simpson's half-brother.[48] | "Oh Brother, Where Art Thou?" |
| Powell, JaneyJaney Powell | Student at Springfield Elementary School. | "Bart the General" |
| Powers, RuthRuth Powers | The Simpsons' next door neighbor.[50] | "New Kid on the Block" |
| Prince, MartinMartin Prince | Student at Springfield Elementary School. | "Bart the Genius" |
| Pryor, Dr. J. LorenDr. J. Loren Pryor | Springfield Elementary School's psychiatrist. | "Bart the Genius" |
| Quimby, Mayor JoeMayor Joe Quimby | Mayor of Springfield. | "Bart Gets an F" |
| Radioactive Man | Comic book superhero. | "Bart the Genius" |
| The, Rich TexanRich Texan The | Philanthropist. | "$pringfield (or, How I Learned to Stop Worrying and Love Legalized Gambling)" |
| Riviera, Dr. NickDr. Nick Riviera | Medical doctor. | "Bart Gets Hit by a Car" |
| Santa's Little Helper | The Simpson family's pet dog. | "Simpsons Roasting on an Open Fire" |
| Sherri and Terri | Identical twins; Students at Springfield Elementary Schools. | "Homer's Odyssey" |
| Shutton, DaveDave Shutton | Reporter for The Springfield Shopper. | "Two Cars in Every Garage and Three Eyes on Every Fish" |
| Sideshow Bob | Criminal mastermind. | "The Telltale Head" |
| Sideshow Mel | The Krusty the Clown Show sidekick. | "Itchy & Scratchy & Marge" |
| Simpson, Grampa AbrahamGrampa Abraham Simpson | Homer Simpson's father; Bart, Lisa, and Maggie Simpson's grandfather. | "Grampa and the Kids" (The Simpsons shorts)[52] |
| Simpson, AmberAmber Simpson | Homer Simpson's deceased "Vegas wife."[21] | "Viva Ned Flanders" |
| Simpson, MonaMona Simpson | Deceased estranged mother of Homer Simpson and wife of Abe Simpson. | "Oh Brother, Where Art Thou?" |
| Skinner, AgnesAgnes Skinner | Seymour Skinner's mother. | "The Crepes of Wrath" |
| Skinner, Principal SeymourPrincipal Seymour Skinner | Principal of Springfield Elementary School. | "Simpsons Roasting on an Open Fire" |
| Smithers, WaylonWaylon Smithers | Monty Burns's personal assistant. | "Homer's Odyssey" |
| Snake | Recidivist. | "The War of the Simpsons" |
| Snyder, Judge RoyJudge Roy Snyder | Springfield judge. | "Krusty Gets Busted" |
| Space Mutants | Monsters of the films of the same name. | "Scary Movie" (The Simpsons shorts)[24] |
| Springfield, JebediahJebediah Springfield | Founder of Springfield; local hero. | "The Telltale Head" |
| Spuckler, CletusCletus Spuckler | Yokel. | "Bart Gets an Elephant" |
| Spuckler, BrandineBrandine Spuckler | Cletus Spuckler's wife and sister. | "Scenes from the Class Struggle in Springfield" |
| Squeaky-Voiced Teen | Service industry. | "Principal Charming" |
| Szyslak, MoeMoe Szyslak | Owner of Moe's Tavern. | "Simpsons Roasting on an Open Fire" |
| Tatum, DrederickDrederick Tatum | Professional boxer.[55] | "Flaming Moe's" |
| Teeny, Mr.Mr. Teeny | The Krusty the Clown Show trained monkey. |
|
| Terwilliger, CecilCecil Terwilliger | Sideshow Bob's younger brother.[57] | "Brother from Another Series" |
| Tightlips, JohnnyJohnny Tightlips | One of Fat Tony's henchmen.[20] | "Insane Clown Poppy" |
| Üter | Student at Springfield Elementary School. | "Treehouse of Horror IV" |
| Van Houten, KirkKirk Van Houten | Milhouse Van Houten's father; factory worker. | "Bart's Friend Falls in Love" |
| Van Houten, LuannLuann Van Houten | Kirk Van Houten's wife; Milhouse's mother. | "Homer Defined" |
| Van Houten, MilhouseMilhouse Van Houten | Bart Simpson's best friend; Student at Springfield Elementary School. | "Simpsons Roasting on an Open Fire" |
| Velimirovic Dr. Velimirovic | Plastic surgeon.[58] | "Pygmoelian" |
| Veterinarian | Veterinarian.[59] | "Dog of Death" |
| Wiggum, Chief ClancyChief Clancy Wiggum | Springfield Chief of Police. | "Homer's Odyssey" |
| Wiggum, RalphRalph Wiggum | Student at Springfield Elementary School. | "Moaning Lisa" |
| Wiggum, SarahSarah Wiggum | Chief Wiggum's wife; Ralph Wiggum's mother. | "Duffless" |
| Groundskeeper Willie | Janitor of Springfield Elementary School. | "Principal Charming" |
| Wiseguy | Service industry. | "The Way We Was" |
| Wolfcastle, RainierRainier Wolfcastle | Actor; star of McBain films. | "The Way We Was" |
| Yes Guy[12] | Service industry. | "Mayored to the Mob" |
| Ziff, ArtieArtie Ziff | Former billionaire.[61] | "The Way We Was" |
